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Principal Scientist, Translational Modeling and Simulation

Company: Amazon Workforce Staffing
Location: Milford
Posted on: September 12, 2020

Job Description:

Principal Scientist, Translational Modeling and Simulation Company: Pfizer

Location: Cambridge

Posted on: August 9, 2020

Job Description:

ROLE SUMMARY

The successful applicant will join the Translational Modeling andSimulation team within Pfizer's Medicine Design organization whichapplies state-of-the-art modeling and simulation methodologies topreclinical programs to enable key drug discovery decisions fromearly discovery stages through early -clinical studies. As a memberof Cambridge (US)-based multidisciplinary project teams, thecandidate will develop and implement quantitative, mechanism-basedmathematical models which impact decisions regarding moleculartarget and interventional modality evaluation, biomarkercharacterization, chemical optimization and candidate selection,preclinical-clinical translation strategies and early clinicaltrial design.

ROLE RESPONSIBILITIES

As a member preclinical multidisciplinary project teams,develop and implement translational pharmacology and safetystrategies in support of the design, characterization andnomination of molecules for clinical development

Influence the design and interpretation of in vitro and in vivoADME, pharmacology and safety studies underwriting drug design andclinical candidate identification

Hands-on development and implementation of robust,fit-for-purpose mathematical models (e.g. PBPK, PKPD, QSP) tosupport study design, data analysis and decision making.

Partner with members of early clinical development teams toensure end-to-end alignment with translational plans, knowledgetransfer into early clinical development, and extract learningsfrom clinical experience.

Partner with other members of Translational Modeling andSimulation to advance the discipline of quantitative translationalpharmacology

Partner with members of Pharmacokinetics, Dynamics andMetabolism to advance the discipline of small-molecule ADMEsciences

Remain abreast of emerging literature in quantitativetranslational sciences and present scientific results bothinternally and externally through conference presentations andpublications

BASIC QUALIFICATIONS

Ph.D. or Masters degree in pharmacometrics, pharmaceuticalsciences, engineering, applied mathematics, systems pharmacology,physics or similar disciplines where modeling and simulation isemphasized.

3 years with a Phd or 8 years with a Masters degree of relevantexperience in practical applications of modeling and simulation(PBPK, PKPD, QSP) in pharmaceutical research and development

Subject matter expertise in the mechanisms of drug disposition,pharmacology and toxicology of small molecule therapeutics.

Strong technical communication skills, ability to workindependently and in teams, and attention to detail areessential.

Familiarity with the phases of drug discovery and development,with emphasis on lead optimization, clinical candidateidentification/characterization, and early clinical development

PREFERRED QUALIFICATIONS

Experience in the application of translational modeling andsimulation to areas of inflammation, immunology, cardiovascular,metabolic diseases, rare disease or oncology is desirable, thoughnot required.

#LI-PFE

Other Job Details:

Eligible for Relocation Package

Eligible for Employee Referral Bonus

Sunshine Act

Pfizer reports payments and other transfers of value to health careproviders as required by federal and state transparency laws andimplementing regulations. These laws and regulations require Pfizerto provide government agencies with information such as a healthcare provider's name, address and the type of payments or othervalue received, generally for public disclosure. Subject to furtherlegal review and statutory or regulatory clarification, whichPfizer intends to pursue, reimbursement of recruiting expenses forlicensed physicians may constitute a reportable transfer of valueunder the federal transparency law commonly known as the SunshineAct. Therefore, if you are a licensed physician who incursrecruiting expenses as a result of interviewing with Pfizer that wepay or reimburse, your name, address and the amount of paymentsmade currently will be reported to the government. If you havequestions regarding this matter, please do not hesitate to contactyour Talent Acquisition representative.EEO & EmploymentEligibility

Pfizer is committed to equal opportunity in the terms andconditions of employment for all employees and job applicantswithout regard to race, color, religion, sex, sexual orientation,age, gender identity or gender expression, national origin,disability or veteran status. Pfizer also complies with allapplicable national, state and local laws governingnondiscrimination in employment as well as work authorization andemployment eligibility verification requirements of the Immigrationand Nationality Act and IRCA. Pfizer is an E-Verifyemployer.Research and Development

Keywords: Pfizer, Cambridge , Principal Scientist, Translational Modeling and Simulation, Other , Cambridge, Massachusetts

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