Principal Scientist

Company: Amazon
Location: Milford
Posted on: September 12, 2020

Job Description:

Company: Pfizer

Location: Cambridge

Posted on: August 9, 2020

Job Description:

ROLE SUMMARYThe Leukocyte-Tissue Interface (LTI) group islooking for a highly-motivated Principal Scientist to join anewly-formed discovery group tasked with developing a cutting-edge,collaborative research program on the interactions of parenchymaltissues with resident and infiltrating leukocytes as applied todiseases in areas of Inflammation, Internal Medicine, and Oncologythat will have cross-research unit impact and delivery.

The Principal Scientist will support a new cross-disciplinary teamof scientists with expertise in Inflammation and Immunology(autoimmunity) and Internal Medicine (metabolic and cardiovasculardisease) or Oncology that leverages cross-research unit science andexpertise to support the development of novel therapeutics at theintersection between immunology and these respective disciplines.He/She will effectively and rapidly advance the biologic foundationin breaking areas of science using cutting edge technologiesincluding optical microscopy and high content screening, systemsimmunology and single cell RNA techniques (scRNAseq, spatialtranscriptomics, perturb-seq). The Principal Scientist will reportto the head of the Leukocyte-Tissue Interface group and will beresponsible for establishing and maintaining collaborations betweenthe Inflammation and Immunology and Internal Medicine / OncologyResearch Units, as well as preparing and presenting new targetspackages for potential portfolio entry.ROLE RESPONSIBILITIES

Liaise will partners in the collaborating research unit toidentify key areas of biology for new targets discovery.

Utilize diseased tissues, sourced from experimental animalmodels and biopsies obtained from patients to better understandtissue-immune system cross-talk,

Prepare proposals identifying novel drug targets to selectivelymodulate pathologic tissue states.

Integrate internal and external datasets to identify potentialtargets and support the development novel portfolio projects withinthe Inflammation and Immunology Research Unit.

Ensure scientific excellence in the design, execution,analysis, and interpretation of experiments in the context ofapplied research.

Guarantee that data generation, analysis, and retention ishandled in a compliant manner ensuring the highest quality andintegrity of findings.

Support the basic science effort at Pfizer by deliveringquality assays and datasets to support the development newportfolio programs.

Contributes to the delivery of a required number of new assays,platforms, and portfolio programs per year of high quality.

Influences the global external environment throughparticipation at national and international meetings and visibleand active engagement with key scientific opinion leaders to ensurethe group makes the appropriate investments.

Champions projects generated internally, via externalcollaborations, collaboration with Pfizer's Center for TherapeuticInnovation (CTI), or from unique partnering opportunities, thusensuring a robust and competitive portfolio of programs andplatforms for IIRUand the partnering RUs.

QualificationsMust-Have

Ph.D. or equivalent training.

5-7 years of relevant research experience in discoveryscience.

Preferred minimum 3 years of experience in pharmaceuticalR&D.

Strong working knowledge of medical issues, immunology andinflammation.

Demonstrated ability to work across functions and lines in amatrix environment.

Combines knowledge from multiple sources to generate novel andhigh impact ideas. Gets to the core of the problem, asks insightfuland probing questions and gets to the next steps effectively.

Record of delivering quality assays and datasets that empowerthe generation of new programs.

Demonstrated ability to apply knowledge, techniques and skillsto identify new, 'druggable' targets.

Established history of working well in a team environment andcollaborating with other scientists to complement individual areasof expertise with partner capabilities.

Strong communication and presentation skills. Ability todisseminate complex scientific findings in a concise manner to abroad audience.

Nice-to-Have

Experience in select core biology themes including stromalcell-leukocyte cross-talk within the gut-liver axis, role of ECM inintercellular communication, tissue resident immunity, role of stemcell niches in inflammation and tissue repair, and contribution oflocal parenchymal cells in the initiation, maintenance, andresolution of inflammation.

Ability to work with and integrate large datasets in order toidentify core pathways and targets of therapeutic interest to thedepartment.

Background in the intersection of Inflammation and MetabolicDisease or Inflammation and Oncology.

#LI-PFE

Other Job Details:

Eligible for Relocation Package

Eligible for Employee Referral Bonus

Sunshine Act

Pfizer reports payments and other transfers of value to health careproviders as required by federal and state transparency laws andimplementing regulations. These laws and regulations require Pfizerto provide government agencies with information such as a healthcare provider's name, address and the type of payments or othervalue received, generally for public disclosure. Subject to furtherlegal review and statutory or regulatory clarification, whichPfizer intends to pursue, reimbursement of recruiting expenses forlicensed physicians may constitute a reportable transfer of valueunder the federal transparency law commonly known as the SunshineAct. Therefore, if you are a licensed physician who incursrecruiting expenses as a result of interviewing with Pfizer that wepay or reimburse, your name, address and the amount of paymentsmade currently will be reported to the government. If you havequestions regarding this matter, please do not hesitate to contactyour Talent Acquisition representative.EEO & EmploymentEligibility

Pfizer is committed to equal opportunity in the terms andconditions of employment for all employees and job applicantswithout regard to race, color, religion, sex, sexual orientation,age, gender identity or gender expression, national origin,disability or veteran status. Pfizer also complies with allapplicable national, state and local laws governingnondiscrimination in employment as well as work authorization andemployment eligibility verification requirements of the Immigrationand Nationality Act and IRCA. Pfizer is an E-Verifyemployer.Research and Development

Keywords: Pfizer, Cambridge , Principal Scientist - Leukocyte Tissue Interface, Other , Cambridge, Massachusetts

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Keywords: Amazon, Milford , Principal Scientist, Other , Milford, Connecticut